- Women aged 30-39 years with certain risk factors have the same cancer detection rate (CDR) and recall rate (RR) as average-risk women aged 40-49 years.
Why this matters
- Findings suggest that women with 1 or more of 3 risk factors (family history, personal history of breast cancer, dense breasts) will likely benefit from screening starting at age 30 vs 40 years.
- Other studies find that screening at age
- Findings are consistent with recommendations of the American College of Radiology, the American Cancer Society, and the National Comprehensive Cancer Network, among others.
- Retrospective cohort of 2.65 million women with nearly 6 million screening mammograms in the National Mammography Database, 2008-2015.
- Funding: American College of Radiology; University of California, San Francisco.
- Overall, mean CDR was 3.69 (95% CI, 3.64-3.74) per 1000; RR was 9.89% (95% CI, 9.87%-9.92%).
- Overall positive predictive values for biopsy recommended (PPV2) was 20.1% (95% CI, 19.9%-20.4%), and biopsy performed (PPV3) was 28.2% (95% CI, 27.0%-28.5%).
- Women aged 30-39 years with ≥1 of the 3 risk factors had similar CDRs and RRs as average-risk women aged 40-49 years.
- Retrospective, observational design.
- No data on mortality.