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Clinical Summary

Atopic dermatitis and the risk of metabolic syndrome

Takeaway

  • Patients with moderate-to-severe atopic dermatitis (AD) had overrepresentation of the metabolic syndrome and its components (obesity, hypertension, dyslipidaemia and diabetes).
  • Findings suggest that severely-affected patients with AD should be screened for metabolic syndrome.

Why this matters

  • The councilors of the International Eczema Council recently suggested that AD is associated with overrepresentation of several metabolic disorders.
  • However, data regarding the association between AD and metabolic syndrome are controversial.

Study design

  • This cross-sectional study included 116,816 patients with AD and 116,812 age- and sex-matched control individuals.
  • The association between AD and metabolic syndrome, its components, and possible complications in the entire population, adults (ages, >18 years; n=45,157) and adults with moderate to severe AD (n=1909) was evaluated.
  • Funding: None.

Key results

  • Patients with AD had higher prevalence of dyslipidaemia and lower prevalence of diabetes and metabolic syndrome (P<.001 for all).
  • Compared with the control group, patients with moderate and severe AD had higher prevalence rates of (P<.001 for all):
    • metabolic syndrome (17.0% vs 9.4%)
    • obesity (22.2% vs 18.6%)
    • diabetes (15.9% vs 9.2%)
    • hypertension (27.9% vs 15.3%)
    • dyslipidaemia (47.1% vs 28.5%)
    • cardiovascular morbidity
      • ischaemic heart disease (9.3% vs 5.1%)
      • congestive heart failure (2.7% vs 1.2%)
      • prior stroke (4.4% vs 2.4%)
      • peripheral vascular disease (3.0% vs 1.2%).
  • After adjustment for potential confounders, consistent results were observed.

Limitations

  • Risk of incidence-prevalence bias and temporal bias.

References


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