Atopic dermatitis linked to increased risk of coeliac disease

  • Shalom G & al.
  • Am J Clin Dermatol
  • 2 Nov 2019

  • International Clinical Digest
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Takeaway

  • Atopic dermatitis (AD) is associated with increased risk for coeliac disease, according to a large, cross-sectional study.

Why this matters

  • This study suggests that patients with AD should be screened for gastrointestinal morbidities.

Key results

  • Patients with AD had higher prevalence of coeliac disease compared with control patients (0.6% vs 0.4%; P<.001 style="list-style-type:circle;">
  • In subgroup analysis, this association was also significant for adult patients (0.6% vs 0.3%; P<.001 and adult patients with moderate to severe ad vs p=".001).</li">
  • AD was associated with increased prevalence of coeliac disease in multivariate analysis (OR, 1.609; P<.001 style="list-style-type:circle;">
  • OR, 1.652 (P<.001 for adult patients.>
  • OR, 2.132 (P=.006) for adults with moderate to severe AD.
  • Study design

    • 116,816 patients with AD (45,157 adults, 1909 adults with moderate to severe disease) were compared with matched control subjects and analysed for prevalence of coeliac disease.
    • Funding: None.

    Limitations

    • Observational study of large database.

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