Atopic dermatitis severity is linked to cognitive dysfunction

  • Silverberg JI & al.
  • J Am Acad Dermatol
  • 16 May 2020

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Increasing severity of atopic dermatitis is associated with cognitive dysfunction in adults, according to a prospective, questionnaire-based study.

Why this matters

  • The relationship between atopic dermatitis severity and cognitive function is poorly understood.

Key results

  • 12.4% of patients had mild cognitive dysfunction, 5.4% had moderate cognitive dysfunction, and 5.2% had severe dysfunction.
  • Increased atopic dermatitis severity was associated with decreased cognitive function.
    • Significant outcomes (P<.05 were found for patient-reported global atopic dermatitis numerical rating scale worst-itch patient oriented eczema measure scoring dermatitis-sleep poem-sleep and nrs skin-pain.>
  • Cognitive function was inversely associated with Dermatology Life Quality Index (P=.002) and Itchy Quality of Life (P<.0001 scores.>

Study design

  • 386 adult patients with atopic dermatitis were evaluated for cognitive function by the Patient-Reported Outcomes Measurement Information System Cognitive Function 8-item short form.
  • Funding: Agency for Healthcare Research and Quality; Dermatology Foundation; Galderma, LLC.

Limitations

  • Self-reported data.
  • Uncontrolled single-center study.