- Atopic dermatitis (AD) is associated with an increased long-term risk of atrial fibrillation (Afib) in specific patient subgroups, according to analysis of population-based Danish registries from 1977 to 2013.
Why this matters
- This study suggests that many patients with AD should be educated on preventative measures for Afib.
- 35-year risk of Afib was 0.81% in patients with AD and 0.67% in patients without AD.
- AD was associated with increased risk of Afib in unadjusted analysis (HR, 1.2; 95% CI, 1.0-1.6), but the association lost significance after adjustment for Afib risk factors and education level (HR, 1.2; 95% CI, 0.9-1.5).
- In multivariate subgroup analysis, AD was significantly associated with increased risk of Afib in females (HR, 1.6; 95% CI, 1.1-2.3), patients aged 0-19 years (HR, 1.6; 95% CI, 1.1-2.4), patients with allergic asthma/rhinitis (HR, 1.7; 95% CI, 1.1-2.4), and patients with ≥8 AD contacts (HR, 4.0; 95% CI, 1.3-12.6).
- 13,126 patients with AD and 124,211 control subjects were analysed over a median follow-up of 19.3 years.
- Funding: None.
- Observational study of large database.