- Maternal sleep-disordered breathing (SDB) is associated with increased nighttime glucose levels and may complicate glucose control in pregnancy.
Why this matters
- Maternal SDB increases with pregnancy progression and is associated with gestational diabetes mellitus (GDM) risk, so data on association between SDB and glucose levels can inform glucose control strategies.
- Cross-sectional study of 65 pregnant women with GDM who underwent polysomnography and 72-hour continuous glucose monitoring.
- Mean age 35 years, mean BMI 32 kg/m2, mean 29 weeks gestation, 33% took insulin/metformin.
- Funding: NIH.
- Mean apnea-hypopnea index (AHI) 16.1.
- Mean oxygen desaturation index 3.0.
- AHI was positively correlated with mean 24-hour glucose (r=0.28, P=.04) before adjustment for age, BMI, and insulin/metformin use but not after (P=.1).
- Increasing AHI showed positive association with increased glucose levels during early sleep (11 p.m.-3 a.m.; Β=0.02, P=.04) and late sleep (3-6 a.m.; Β=0.02; P=.02) after adjustment.
- No association between AHI and daytime glucose (8 a.m.-8 p.m.).
- Adjusted prediction model: 30-year-old unmedicated pregnant woman with AHI ≥30 and BMI 30 “expected to have ~12% increase in mean nocturnal glucose levels” compared with no SDB.