- The use of oral contraceptives and intrauterine devices (IUDs) was associated with an increased risk of developing cervical intraepithelial neoplasia grade III or worse (CIN3+) vs no contraception.
- The risk for CIN3+ was higher with oral contraceptives vs IUDs.
Why this matters
- A pooled analysis of epidemiological studies suggested IUD use may be a protective cofactor in the risk for cervical cancer.
- 702,037 women aged 29-44 years attended a cervical cancer screening program with normal cytology during 2005-2009.
- Funding: None.
- 0.96% of women developed CIN3, and 0.08% were diagnosed with cervical cancer during median follow-up of 9.7 years.
- 25.4% of women used no contraceptive, 12.2% used oral contraceptives, and 3.9% used an IUD for ≥5 years.
- IUD use was associated with an increased risk of developing CIN3+ (risk ratio [RR], 1.51; 95% CI, 1.32-1.74), but not the risk for cervical cancer (RR, 1.21; 95% CI, 0.71-2.07) vs no contraception.
- Oral contraceptives were associated with an increased risk for CIN3+ (RR, 2.77; 95% CI, 2.65-3.00) and cervical cancer (RR, 2.06; 95% CI, 1.52-2.79) vs no contraception.
- Use of oral contraceptives was associated with a higher risk for CIN3+ (RR, 1.83; 95% CI, 1.60-2.09) and cervical cancer (RR, 1.70; 95% CI, 1.00-2.90) vs IUDs.
- Women who did not use any type of contraceptive showed a significantly lower risk for CIN3+ (RR, 0.61; 95% CI, 0.58-0.64) and cervical cancer (RR, 0.63; 95% CI, 0.53-0.75) vs the total group.
- Observational design.