- Nearly 30% of patients with bladder cancer who received neoadjuvant chemotherapy (NACT) failed to complete their regimen.
- Older age was an independent factor for failure to complete NACT.
- Significant regional variation was observed; patients from the central United States had lower odds of failure of completing NACT.
Why this matters
- Identifying risk factors for not completing NACT may help decision making.
- 594 patients with bladder cancer underwent cystectomy between 2004 and 2013, and received NACT within 6 months.
- Funding: None disclosed.
- 29% of patients did not complete NACT.
- Age and geographic region showed independent association with failing to complete NACT:
- Patients aged ≥80 years were more likely to fail to complete NACT vs those aged 66-69 years (aOR, 2.6; 95% CI, 1.4-4.8).
- Patients from the central region were less likely to fail to complete NACT vs those from the northeast region (aOR, 0.3; 95% CI, 0.2-0.6).
- Increased comorbidity was not associated with risk for noncompletion (P>.05).
- Retrospective design.