BMI not associated with FET outcomes in patients with PCOS

  • BMC Pregnancy Childbirth

  • International Clinical Digest
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Takeaway

  • BMI is not significantly associated with pregnancy or perinatal outcomes in patients with polycystic ovary syndrome (PCOS) undergoing frozen embryo transfer (FET).

Why this matters

  • The effects of BMI on pregnancy outcomes in women with PCOS undergoing FET were unclear.

Key results

  • BMI ≥30 kg/m2 ("obese") and BMI 18.5-24.9 kg/m2 ("normal") were associated with similar odds of clinical pregnancy (OR, 0.47; 95% CI, 0.05-3.57), miscarriage (OR, 1.33; 95% CI, 0.88-1.98), ongoing pregnancy (OR, 0.96; 95% CI, 0.53-1.72), live birth (OR, 0.62; 95% CI, 0.18-2.49), delivery
  • Similar results were observed for BMI 25-29.9 kg/m2 ("overweight") vs BMI 18.5-24.9 kg/m2.

Study design

  • 1680 women with PCOS undergoing FET were stratified by BMI (972 normal, 480 overweight, 228 obese) and analysed for pregnancy and perinatal outcomes.
  • Funding: National Natural Science Foundation of China; National Key Research and Development Program of China.

Limitations

  • Retrospective study.