- Endometrial cancer risk was positively associated with body mass index (BMI), weight, body fat percentage, and fat mass in postmenopausal women.
- Central adiposity, as reflected by waist circumference and waist to hip ratio, may be associated with endometrial cancer risk independent of BMI.
Why this matters
- Findings suggest that body fat percentage and fat mass may not be better indicators of endometrial cancer risk than BMI.
- UK Biobank study of 135,110 post-menopausal women.
- Associations between various measures of body size/composition with the risk of endometrial cancer assessed.
- Funding: None disclosed.
- 706 endometrial cancers were identified, with a mean age at diagnosis of 65.5 years, during a mean follow-up of 6.8 years.
- The HRs for endometrial cancer per 1-standard deviation (SD) increase in BMI, weight, body fat percentage, and fat mass were comparable:
- BMI (HR, 1.71; 95% CI, 1.61-1.82);
- weight (HR, 1.70; 95% CI, 1.60-1.81);
- body fat percentage (HR, 1.92; 95% CI, 1.75-2.11); and
- fat mass (HR, 1.73; 95% CI, 1.63-1.85).
- However, in terms of X2 statistics, BMI was the most informative marker (X2 values for BMI, weight, body fat percentage, and fat mass were 509, 499, 456, and 501, respectively).
- After adjustment for BMI, central adiposity, as reflected by waist circumference (HRper 1-SD increase, 1.08; 95% CI, 1.00-1.17) and waist to hip ratio (HRper 1-SD increase, 1.13; 95% CI, 1.01-1.26), was positively associated with endometrial cancer risk.
- Hip circumference and fat-free mass were not associated with the endometrial cancer risk independent of BMI.
- Study largely reflects associations with type I tumours.