- Women with breast cancer vs women without cancer appear to have higher overall mortality and higher cardiovascular disease (CVD)-related mortality after 25 years of follow-up, according to this analysis from the CLUE II cohort study.
Why this matters
- Clinicians should monitor and treat CVD-related conditions in long-term survivors of breast cancer.
- Community-based prospective cohort study (n=628 women with breast cancer and 3140 age-matched participants without cancer).
- Funding: NIH; Breast Cancer Research Foundation.
- After 25-year follow-up, survivors of breast cancer had an almost 80% greater overall risk for mortality than control participants:
- aHR, 1.79 (95% CI, 1.53-2.09).
- Mortality risk was highest among older survivors (age ≥70 years) who were >15 years postdiagnosis:
- aHR, 2.69 (95% CI, 1.59-4.55).
- CVD was the foremost cause of death among control participants and the second leading cause among survivors of breast cancer.
- Survivors vs control participants had a 65% greater risk for CVD-related death starting 8 years after diagnosis:
- aHR, 1.65 (95% CI, 1.00-2.73).
- The greatest risk was seen:
- Among older survivors: aHR, 2.24 (95% CI, 1.29-3.88).
- With estrogen receptor-positive disease: aHR (1.85; 95% CI, 1.06-3.20).
- Unable to perform subgroup analysis of breast cancer treatment type.