- Patients with breast cancer are at risk of dying from breast cancer, but they also are at risk for death from other solid tumors, according to a nationwide Swedish prospective cohort.
Why this matters
- Findings warrant stepped-up surveillance for other solid tumors.
- Prospective nationwide cohort of 57,501 patients with breast cancer (2001-2011) from the Swedish Cancer Registry, matched by year of birth, county of residence, and socioeconomic status with 564,703 women from the general population.
- Incidence and mortality were tracked, and P values were set at P<.00022 because of multiple comparisons.>
- Funding: Swedish Research Council; others.
- Median follow-up was 5.3 years in patients with breast cancer and 5.8 years for control participants.
- Of 225 diseases under study, 45 among patients with breast cancer had HRs >1.5 and P<.00022.>
- In terms of disease incidence, the highest HRs were for lymphedema, radiodermatitis, menopausal disorders, and neutropenia, all of which are adverse events related to surgery, radiotherapy, and chemotherapy.
- In terms of mortality, the greatest risk was breast cancer (n=5405; HR not specified), followed by other solid tumors (n=890; HR, 1.16; 95% CI, 1.08-1.24).
- No other causes of death were significant.
- Observational design.
- Some HRs not specified.