- A case-series in China of 203 breast cancers diagnosed during pregnancy (pregnancy-associated breast cancers; PABCs) finds disproportionately high luminal B and triple-negative breast cancer (TNBC) and moderately high 3-year DFS of 80.3%.
Why this matters
- The incidence of PABC, although rare, is increasing, and outcomes are somewhat worse than with non-PABCs.
- Case-series of 203 PABCs from Fudan University, Shanghai Cancer Center (2005-2018).
- Descriptive analysis of tumor characteristics and DFS.
- Funding: National Natural Science Foundation of China; Fudan University.
- 11.3% of the 203 patients chose to have an abortion and receive immediate treatment.
- 32.5% chose to delay treatment until delivery.
- 56.2% were diagnosed during the lactation period.
- Patients with PABC vs without PABC were more likely to have:
- Luminal B cancer: 38.4% vs 20.1% (P<.001>
- TNBC: 30.1% vs 17.4% (P<.001>
- HER2+ breast cancer: 15.8% vs 8.0% (P<.001>
- Single-center study.
- Retrospective, observational design.