Breast cancer diagnosed during pregnancy: 203 cases in China

  • BMC Cancer

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A case-series in China of 203 breast cancers diagnosed during pregnancy (pregnancy-associated breast cancers; PABCs) finds disproportionately high luminal B and triple-negative breast cancer (TNBC) and moderately high 3-year DFS of 80.3%.

Why this matters

  • The incidence of PABC, although rare, is increasing, and outcomes are somewhat worse than with non-PABCs.

Study design

  • Case-series of 203 PABCs from Fudan University, Shanghai Cancer Center (2005-2018).
  • Descriptive analysis of tumor characteristics and DFS.
  • Funding: National Natural Science Foundation of China; Fudan University.

Key results

  • 11.3% of the 203 patients chose to have an abortion and receive immediate treatment.
  • 32.5% chose to delay treatment until delivery.
  • 56.2% were diagnosed during the lactation period.
  • Patients with PABC vs without PABC were more likely to have:
    • Luminal B cancer: 38.4% vs 20.1% (P<.001>
    • TNBC: 30.1% vs 17.4% (P<.001>
    • HER2+ breast cancer: 15.8% vs 8.0% (P<.001>
  • Across all patients with PABC, the 3-year DFS was 80.3%.
  • No differences in 3-year DFS among the 3 groups.
  • No differences in 3-year DFS for women in their first pregnancy and those in second or later pregnancies.

Limitations

  • Single-center study.
  • Retrospective, observational design.