- 7-year data show that accelerated partial breast irradiation (APBI) delivered with 3D conformal external beam radiation (3D-CRT) yields 95.2% 7-year PFS and good-to-excellent cosmesis in 75.2% of patients with early breast cancer.
Why this matters
- This is the longest study to date of external-beam ABPI.
- Retrospective cohort of 266 patients undergoing APBI delivered with 3D-CRT during 2006-2012 at the Washington University School of Medicine with >1 year of follow-up.
- Funding: None.
- Median follow-up, 87 (range, 13-156) months.
- 60.9% of cohort was "suitable" for APBI, 32.7% were "cautionary," and 6.4% were "unsuitable," according to consensus groupings by the American Society for Radiation Oncology (ASTRO).
- Ipsilateral breast tumor recurrence (IBTR) was 1.8%.
- PFS was 95.2%.
- Margin status (
- 75.2% had good to excellent cosmesis, and 24.8% had fair to poor.
- 2 patients (0.8%) had poor cosmesis warranting plastic surgery.
- Adverse cosmesis was associated with greater percentage of irradiated breast (OR, 1.101; P=.021) and higher dose per fraction (400 cGy vs 385 cGy; P=.039).
- Retrospective, observational design.
- Single-center study may limit generalizability.