- Casting-type calcification on mammography, a subtype of microcalcification, may be indicative of poorer prognosis in breast cancer (BCa), including decreased disease-free survival (DFS) and OS.
Why this matters
- The presence of mammographic casting-type calcifications is an independent prognostic factor that may warrant more aggressive treatment.
- Retrospective cohort of 1155 patients with invasive BCa who underwent definitive BCa surgery.
- Funding: Beijing Natural Science Foundation; others.
- 11.8% of the cohort had casting-type calcification on mammogram.
- Casting-type calcification was more likely associated with:
- Axillary node metastasis vs no metastasis (OR, 1.98; P=.001).
- Estrogen receptor negativity vs positivity (OR, 1.49; P=.035).
- Human epidermal growth factor receptor 2 (HER2) overexpression vs HER2-negative (OR, 2.39; P<.001>
- A trend toward higher histologic grade (G2 vs G1; OR, 1.62; P=.063).
- Shorter DFS vs no casting group (78.34% vs 90.50%; adjusted HR, 1.65; P=.024).
- Shorter OS vs no casting group (84.53% vs 96.80%; adjusted HR, 1.95; P=.026).
- Single-center study.