Breast cancer: mammographic casting-type calcification carries adverse prognosis

  • Li Y & al.
  • Sci Rep
  • 22 Jul 2019

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Casting-type calcification on mammography, a subtype of microcalcification, may be indicative of poorer prognosis in breast cancer (BCa), including decreased disease-free survival (DFS) and OS.

Why this matters

  • The presence of mammographic casting-type calcifications is an independent prognostic factor that may warrant more aggressive treatment.

Study design

  • Retrospective cohort of 1155 patients with invasive BCa who underwent definitive BCa surgery.
  • Funding: Beijing Natural Science Foundation; others.

Key results

  • 11.8% of the cohort had casting-type calcification on mammogram.
  • Casting-type calcification was more likely associated with:
    • Axillary node metastasis vs no metastasis (OR, 1.98; P=.001).
    • Estrogen receptor negativity vs positivity (OR, 1.49; P=.035).
    • Human epidermal growth factor receptor 2 (HER2) overexpression vs HER2-negative (OR, 2.39; P<.001>
    • A trend toward higher histologic grade (G2 vs G1; OR, 1.62; P=.063).
  • The casting group, after a median follow-up of 60 months, was associated with:
    • Shorter DFS vs no casting group (78.34% vs 90.50%; adjusted HR, 1.65; P=.024).
    • Shorter OS vs no casting group (84.53% vs 96.80%; adjusted HR, 1.95; P=.026).

Limitations

  • Single-center study.

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