- Patients with breast cancer who are nonadherent to cardiovascular disease risk factor (CVD-RF) medications may have a 15% increased risk for a cardiac event.
Why this matters
- CVD is the foremost cause of death among patients with early breast cancer (eBCa).
- Retrospective cohort (n=15,576) of the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database of patients with prescription drug coverage and who were taking at least 1 CVD-RF medication before their BCa diagnosis (2008-2013).
- Medication adherence was defined as a medication possession ratio of ≥80%.
- Funding: American Society of Clinical Oncology; others.
- 30.8% of patients were nonadherent to ≥1 CVD-RF drug category after being treated for BCa.
- Nonadherence was associated with:
- black race (OR, 1.15; P=.03);
- greater comorbidity burden (OR, 1.85; P<.0001>
- more advanced cancer stage (OR, 1.15; P=.0002);
- having received chemotherapy (OR, 1.14; P=.005); and
- hormone receptor-negative disease (OR, 1.13; P=.02).
- nonadherence to hypertension medication (HR, 1.33; P<.0001>
- nonadherence to hyperlipidemia medication (HR, 1.21; P=.009); and
- nonadherence to diabetes medication (HR, 1.31; P=.003).
- Retrospective observational design.