Breast cancer: physical activity tied to lower recurrence, mortality in DELCaP study

  • Cannioto RA & al.
  • J Natl Cancer Inst
  • 2 Apr 2020

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Recreational physical activity (RPA) before and after high-risk breast cancer diagnosis is associated with ≥40% lower recurrence and mortality.

Why this matters

  • Patients should be highly encouraged to engage in RPA.

Study design

  • Prospective cohort (n=1340) from the DELCaP study (SWOG S0221), using questionnaires that included RPA questions.
  • RPA was defined as 5 overlapping types: inactive, meeting the minimum guidelines (≥150 minutes of moderate-intensity RPA/week), low active (16 hours/week).
  • Funding: NIH; others.

Key results

  • Patients meeting the minimum guidelines vs being inactive before and 1 year after diagnosis had:
    • 41% lower risk for recurrence:
      • HR, 0.59 (95% CI, 0.42-0.82). 
    • 49% lower all-cause mortality:
      • HR, 0.51 (95% CI, 0.34-0.77).
  • Patients meeting the minimum guidelines vs being inactive before and 2 years after diagnosis had:
    • 55% lower risk for recurrence:
      • HR, 0.45 (95% CI, 0.31-0.65). 
    • 68% lower all-cause mortality at 1-year follow-up:
      • HR, 0.32 (95% CI, 0.19-0.52).
  • When all times were considered together, vs inactivity, there were strong survival benefits (HRs; 95% CIs) with:
    • Low activity: 0.41 (0.24-0.68).
    • Moderate activity: 0.42 (0.23-0.76).
    • High activity: 0.31 (0.18-0.53).

Limitations

  • High-risk breast cancer not defined.
  • Observational design.
  • Relatively short follow-up.