- A physical exercise intervention reduces fatigue and improves physical functioning in patients with breast cancer, according to a meta-analysis.
Why this matters
- Up to 99% of all patients with breast cancer suffer from fatigue during adjuvant chemotherapy that impairs physical functioning and QoL.
- Meta-analysis of 25 randomized controlled trials (n=3418) that met eligibility criteria after search on Cochrane Library, MEDLINE, EMBASE, CINAHL, PsycINFO, AMED, and PEDro.
- Funding: None disclosed.
- A physical exercise intervention increases physical functioning (standardized mean difference [SMD]=0.27; 95% CI, 0.13-0.41) and decreases fatigue (SMD=−0.32; 95% CI, −0.49 to −0.14) independent of when the intervention is given.
- Somewhat greater improvements in physical function and fatigue occurred when the intervention was given after adjuvant treatment.
- Benefits for both physical function and fatigue lasted to 6-mo follow-up.
- Heterogeneity across primary studies.