Breast cancer: soy foods tied to lower fracture risk in younger survivors

  • JNCI Cancer Spectr

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
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Takeaway

  • High soy food intake was associated with lower risk for osteoporotic fractures in pre-/perimenopausal survivors of early breast cancer in the Shanghai Breast Cancer Survival Study.
  • High exercise is tied to reduced risk for osteoporotic fractures in postmenopausal survivors.

Why this matters

  • Patients with breast cancer have a higher risk for osteoporosis-related fractures than age-matched healthy women, largely as a result of therapies that induce estrogen deprivation.
  • If confirmed, high soy food intake and exercise may be recommended to patients.

Study design

  • Prospective cohort of women with early breast cancer (n=4139 stage 0-III) assessed for osteoporotic fractures up to 10 years postdiagnosis.
  • Soy food intake assessed by validated food frequency questionnaire at 6 and 18 months postdiagnosis.
  • Funding: US Department of Defense; NIH.

Key results

  • 10-year incidence of osteoporotic fractures was 2.9% in pre-/perimenopausal survivors and 4.4% in postmenopausal survivors.
  • High (vs low) soy food intake was associated with lower risk for osteoporotic fractures in pre-/perimenopausal survivors (HR, 0.22; 95% CI, 0.09-0.53; Ptrend<.001 but not in postmenopausal survivors.>
  • High (vs low) exercise was associated with lower risk for osteoporotic fractures in postmenopausal survivors (HR, 0.56; 95% CI, 0.33-0.97) with dose-response (Ptrend<.035 but not pre- survivors.>

Limitations

  • Observational design.