C-reactive protein levels high in patients with obstructive sleep apnoea

  • Van der Touw T & al.
  • Biomarkers
  • 25 Mar 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • This meta-analysis revealed that high-sensitivity C-reactive protein (hsCRP) levels were significantly increased in patients with obstructive sleep apnoea (OSA) without co-morbidities compared with that in healthy control participants.
  • Pharyngeal or systemic inflammatory effects associated with OSA may increase the CRP levels.

Why this matters

  • Findings support clinical monitoring of CRP in assessing the effects of continuous positive airway pressure on cardiovascular disease risk in patients with OSA.

Study design

  • Meta-analysis of 5 studies comparing hsCRP levels in non-smoking patients with OSA (n=219) and healthy control group (n=116) identified after a search across electronic databases.
  • Funding: None.

Key results

  • Patients with OSA showed significantly higher mean hsCRP level compared with the control group (mean difference, 0.61 mg/dL; 95% CI, 0.38-0.84; P<.00001>
  • Mean serum hsCRP levels were not significantly correlated with body mass index (P<.17 age and sex composition in patients with osa the control group.>

Limitations

  • Study cannot guarantee that comorbidities were absent in all cases.
  • Small sample size and number of studies.

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