- This meta-analysis revealed that high-sensitivity C-reactive protein (hsCRP) levels were significantly increased in patients with obstructive sleep apnoea (OSA) without co-morbidities compared with that in healthy control participants.
- Pharyngeal or systemic inflammatory effects associated with OSA may increase the CRP levels.
Why this matters
- Findings support clinical monitoring of CRP in assessing the effects of continuous positive airway pressure on cardiovascular disease risk in patients with OSA.
- Meta-analysis of 5 studies comparing hsCRP levels in non-smoking patients with OSA (n=219) and healthy control group (n=116) identified after a search across electronic databases.
- Funding: None.
- Patients with OSA showed significantly higher mean hsCRP level compared with the control group (mean difference, 0.61 mg/dL; 95% CI, 0.38-0.84; P<.00001>
- Mean serum hsCRP levels were not significantly correlated with body mass index (P<.17 age and sex composition in patients with osa the control group.>
- Study cannot guarantee that comorbidities were absent in all cases.
- Small sample size and number of studies.