Caffeine intake during pregnancy is overall not associated with neonatal health

  • Modzelewska D & al.
  • BMC Pregnancy Childbirth
  • 26 Feb 2019

  • curated by Elisabeth Aron, MD, MPH, FACOG
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Caffeine intake during pregnancy was associated with risk for small for gestational age (SGA), which in turn was linked to neonatal complications.
  •  Overall caffeine intake was not associated with effects on neonatal health, even with adjustment for SGA.

Why this matters

  • Women during pregnancy often seek advice on caffeine, which crosses the placenta.

Key results

  • Median caffeine intake was 58 mg; 75% consumed
  • Total caffeine intake was not associated with (aORs): 
    • neonatal morbidity, mortality: 1.01 (P=.88); or
    • neonatal intervention: 1.02 (P=.07). 
    • Adjustment for SGA did not change these associations.
  • Caffeine exposure was associated with SGA (OR, 1.16; 95% CI, 1.10-1.23), but the authors suggest various underlying causes for the SGA.
  • Infants with SGA had increased risk for (ORs; 95% CIs):
    • neonatal morbidity, mortality: 3.09 (2.54-3.78); and 
    • neonatal intervention: 3.94 (3.50-4.45).

Study design

  • Cohort from MoBa, a Norwegian prospective population pregnancy cohort.
  • Caffeine intake assessed through self-reported dietary habits by food frequency questionnaire at 22 weeks of gestation.
  • Neonatal outcomes assessed using composite variables: neonatal morbidity or mortality and neonatal intervention.
  • Information on neonatal birth weight and gestational age were abstracted from records.
  • SGA defined as
  • Funding: Erasmus + EU grant.

Limitations

  • Self-reporting bias possible.
  • Most women consumed low levels of caffeine during pregnancy.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit