- Caffeine intake during pregnancy was associated with risk for small for gestational age (SGA), which in turn was linked to neonatal complications.
- Overall caffeine intake was not associated with effects on neonatal health, even with adjustment for SGA.
Why this matters
- Women during pregnancy often seek advice on caffeine, which crosses the placenta.
- Median caffeine intake was 58 mg; 75% consumed
- Total caffeine intake was not associated with (aORs):
- neonatal morbidity, mortality: 1.01 (P=.88); or
- neonatal intervention: 1.02 (P=.07).
- Adjustment for SGA did not change these associations.
- Caffeine exposure was associated with SGA (OR, 1.16; 95% CI, 1.10-1.23), but the authors suggest various underlying causes for the SGA.
- Infants with SGA had increased risk for (ORs; 95% CIs):
- neonatal morbidity, mortality: 3.09 (2.54-3.78); and
- neonatal intervention: 3.94 (3.50-4.45).
- Cohort from MoBa, a Norwegian prospective population pregnancy cohort.
- Caffeine intake assessed through self-reported dietary habits by food frequency questionnaire at 22 weeks of gestation.
- Neonatal outcomes assessed using composite variables: neonatal morbidity or mortality and neonatal intervention.
- Information on neonatal birth weight and gestational age were abstracted from records.
- SGA defined as
- Funding: Erasmus + EU grant.
- Self-reporting bias possible.
- Most women consumed low levels of caffeine during pregnancy.