- Patients who undergo surgery for chronic pancreatitis (CP) are subsequently at much higher risk of developing pancreatic cancer.
Why this matters
- Clinicians should be vigilant about monitoring patients for pancreatic cancer after CP surgery, particularly those with newly diagnosed diabetes.
- Researchers reviewed the health records of patients who underwent surgery for histologically confirmed CP (N=650), using univariate and multivariate Cox regression analyses to identify independent risk factors associated with progression of pancreatic cancer.
- Funding: Sichuan University; National Natural Science Foundation of China; Scientific and Technological Support Program of Sichuan Province.
- Postoperative cancer was detected in 12 patients (1.8%) after a median follow-up of 4.4 years (range, 11 months-10 years).
- The standardized incidence ratio was 68.12 (95% CI, 35.20-118.99), based on an expected incidence of 0.176.
- Independent risk factors included:
- Time to surgery: HR, 1.005 (95% CI, 1.002-1.008; P=.002).
- Postoperative diagnosis of endocrine insufficiency: HR, 10.672 (2.567-44.372; P=.001).
- The study was retrospective and included a small number of patients who developed pancreatic cancer, limiting statistical power.