Cannabis use disorder tied to epilepsy hospitalizations

  • Patel RS & al.
  • Am J Addict
  • 24 May 2019

  • International Clinical Digest
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Takeaway

  • Inpatients with cannabis use disorder were more than 50% as likely to have a primary diagnosis of epilepsy.

Why this matters

Key results

  • Risk for epilepsy hospitalization higher for patients with vs without cannabis use disorder after adjustment for:
    • Demographics (OR, 1.556; P<.001>
    • All suspected risk factors excluding other substance use disorders (OR, 1.490; P<.001 and>
    • Demographics and all risk factors including tobacco, opioid, amphetamine, cocaine, alcohol abuse disorders (OR, 1.420; P<.001>
  • Among the patients with epilepsy, incidence of cannabis use disorder was 5.8%.
  • Those with cannabis use disorder:
    • Younger (P<.001>
    • More often male and African American (P<.001 for both and>
    • More commonly had preexisting epilepsy risk factors (brain tumor, meningitis, encephalitis, cerebral palsy, stroke, developmental disorders; P<.001 for all>

Study design

  • Retrospective cross-sectional cohort study of Nationwide Inpatient Sample 2010-2014, patients aged 15-54 years:
    • 657,072 with primary diagnosis of epilepsy.
    • 67,575,568 without epilepsy.
  • Main outcome: epilepsy hospitalization.
  • Funding: None.

Limitations

  • Study establishes only correlation.
  • Lack of information on dose, strains, preparations, reasons for use.

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