- An association has been found between cannabis use and increased risk for diabetic ketoacidosis (DKA) in adults with type 1 diabetes (T1D).
Why this matters
- Cannabis-induced alterations to gut motility, food absorption, and postprandial glycaemic timing may be unexpected and inconsistent for cannabis users with T1D.
- Total substance score for cannabis (TSC) and DKA in past 12 months assessed in 932 adults in the T1D Exchange.
- Participants classified by recommended intervention: low risk/none (TSC 0-3; n=871); moderate risk/brief (4-26; n=61); and high risk/intensive (>26; n=0).
- Funding: Helmsley Charitable Trust.
- Compared with no intervention, factors tied to classification by moderate risk/brief intervention included: being male and younger at T1D diagnosis, having less education and higher HbA1c, and being less likely to use continuous glucose or fingerstick monitoring and more likely to use tobacco/other substances.
- No differences in race, insulin pump use, severe hypoglycemia requiring hospitalisation, or alcohol use.
- DKA was associated with a TSC >4 (OR, 2.5; 95% CI, 1.0-5.9) adjusted for sex, age at study visit, and HbA1c.
- Adjustment for legal status of cannabis in state of residence did not alter this association.
- Cannabis use self-reported.
- Cross-sectional design.
- Lack of details about diabetes self-management, adherence.