- Cardiorespiratory fitness (CRF) appears to exert a protective effect against lung cancer in former male smokers.
- Data also point to lower reduced disease-related mortality and longer survival in current male smokers with lung cancer.
Why this matters
- CRF appears to be a modifiable risk factor for lung cancer morbidity and mortality.
- 1602 former and 1377 current male smokers from the Veterans Exercise Testing Study underwent CRF assessment.
- Mean age, 59.1 years; median follow-up, 11.6 years.
- Funding: None disclosed.
- Lung cancer was diagnosed in 99 patients (2.9% of former smokers and 3.8% of current smokers).
- In former smokers, lung cancer incidence was significantly lower in patients with moderate CRF (HR, 0.49; 95% CI, 0.25-0.97) or high CRF (HR, 0.23; 95% CI, 0.08-0.66; Ptrend=.015).
- In current smokers, moderate and high CRF was associated with:
- Lower lung cancer mortality (HR, 0.16; 95% CI, 0.06-0.4 and HR, 0.15; 95% CI, 0.05-0.5, respectively; Ptrend<.001>
- Longer survival time (HR, 10.8; 95% CI, 8.2-13.4 and HR, 12.2; 95% CI, 7.9-16.5, respectively; Ptrend<.001>
- All-male study.
- Observational design.