Takeaway
- Adults (aged 16-64 years) with cerebral palsy (CP) have a higher prevalence of all-cause fracture (6.3%) than adults without CP (2.7%).
- On multivariable analysis, the risk is double, independent of osteoporosis or cardiometabolic disease.
Why this matters
- First epidemiology study to quantify the prevalence of fracture in adults with CP.
- Patients and families should be advised of the higher fracture risk.
Study design
- Cross-sectional cohort of adults with CP (n=5555) and without CP (5.5 million) identified from a large US privately insured claims database, Optum Clinformatics.
- Funding: None disclosed.
Key results
- Adults with CP have a higher prevalence of all-cause fracture (6.3% vs 2.7% in adults without CP; P<.01>
- The most common fractures are in the lower extremities (3.3% vs 1.2%; P<.01 and upper extremities vs p>
- Less common are fractures of the lumbar/pelvis region (0.5% vs 0.2%; P<.01>
- Adults with CP (vs without CP) have 2.5-fold increased risk for all-cause fracture (OR, 2.5; 95% CI, 2.2-2.7).
- After adjusting for cardiometabolic disease, the all-cause fracture risk was still double (OR, 2.2; 95% CI, 2.0-2.5).
- After adjusting for osteoporosis, the risk remained double (OR, 2.0; 95% CI, 1.8-2.2).
Limitations
- Cross-sectional design.
- Unable to trace fracture history or cause.
Only healthcare professionals with a Univadis account have access to this article.
You have reached your limit of complementary articles
Free Sign Up Available exclusively to healthcare professionalsLogin to
account
Don’t have an account? Get started