Cervical cancer: residual lymph node after CRT tied to poor OS

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Takeaway

  • In patients with node-positive cervical cancer, lymph node response was a significant prognostic factor for survival outcomes after chemoradiotherapy (CRT).
  • Primary tumor response did not influence survival.

Why this matters

  • Previous studies focused on primary tumor response to predict clinical outcome.
  • The significance of lymph node response after definitive treatment is not known.

Study design

  • 117 patients with node-positive cervical cancer were treated with definitive CRT between 2006 and 2016.
  • Positive lymph node was defined as a lymph node with a short axis diameter of ≥8 mm.
  • Funding: None disclosed.

Key results

  • Median follow-up duration was 41 months.
  • At 3 months after CRT, 25.6% of patients had residual primary tumor, and 26.5% had residual lymph node.
  • The presence of residual lymph node was associated with worse OS (HR, 3.04; P=.004), local control (HR, 7.97; P<.001 regional control p=".004)," and dfs>
  • Primary tumor response showed no significant association with OS.
  • Positive lymph node showed an area under the curve value of 0.72 in the 5-year time-dependent survival prediction model.

Limitations

  • Retrospective design.