- In patients with node-positive cervical cancer, lymph node response was a significant prognostic factor for survival outcomes after chemoradiotherapy (CRT).
- Primary tumor response did not influence survival.
Why this matters
- Previous studies focused on primary tumor response to predict clinical outcome.
- The significance of lymph node response after definitive treatment is not known.
- 117 patients with node-positive cervical cancer were treated with definitive CRT between 2006 and 2016.
- Positive lymph node was defined as a lymph node with a short axis diameter of ≥8 mm.
- Funding: None disclosed.
- Median follow-up duration was 41 months.
- At 3 months after CRT, 25.6% of patients had residual primary tumor, and 26.5% had residual lymph node.
- The presence of residual lymph node was associated with worse OS (HR, 3.04; P=.004), local control (HR, 7.97; P<.001), regional control (HR, 3.75; P=.004), and DFS (HR, 3.49; P=.003).
- Primary tumor response showed no significant association with OS.
- Positive lymph node showed an area under the curve value of 0.72 in the 5-year time-dependent survival prediction model.
- Retrospective design.