- Early clearance of HPV after definitive chemoradiation is associated with improved survival in patients with cervical cancer.
Why this matters
- 6-week follow-up may represent a critical point at which decisions could be made regarding treatment escalation.
- Study of 97 patients with invasive cervical cancer, treated with definitive intent chemoradiation.
- Funding: None disclosed.
- The mean follow-up time was 25 months.
- 74.2% of patients had early clearance.
- Patients with early clearance (vs persistent expression) were more likely to be infected with HPV-16 (77.8%; P<.01>
- At 2 years, pelvic control (76.9% vs 50.2%; P=.01) and OS (80.9% vs 52.2%; P<.01 were significantly higher in patients with early clearance vs those persistent expression.>
- In patients with complete metabolic response, early clearance vs persistent expression was associated with better:
- Pelvic control: 92.9% vs 61.1% (P=.04).
- Distant control: 94.7% vs 73.3% (P=.02).
- PFS: 90.5% vs 54.7% (P<.01>
- OS: 95.6% vs 66.7% (P=.04).
- Early clearance of HPV: HR, 0.46 (P=.04).
- Less than a complete response on posttreatment PET imaging: HR, 5.52 (P<.01>
- Single-center study.