- Women who receive treatment for cervical intraepithelial neoplasia (CIN) show a 3-fold higher risk of developing cervical cancer vs the general population.
- The incidence rate remains higher even 20 years after the treatment.
- The risk is higher in older women.
Why this matters
- Longer follow-up may be warranted for the high-risk population previously treated for CIN.
- Meta-analysis of 27 studies including 5726 women treated for CIN.
- Funding: National Institute for Health Research.
- Mean follow-up duration varied from 5 to 27.5 years.
- The absolute incidence rate (IR) after treatment of CIN per 100,000 woman-years was 39 (95% CI, 22-69; total of 5,562,889 woman-years).
- IRs per 100,000 woman-years:
- 38 within 10 years of treatment,
- 31 at 10-20 years, and
- 32 after 20 years.
- Women treated for CIN showed a higher relative risk (RR) for cervical cancer vs the general population: 3.30 (95% CI, 2.57-4.24).
- Risk ratio (RR) was higher in older women:
- ≥50 years: 7.15 (95% CI, 4.75-10.76); vs
- The risk for cervical cancer was higher after excisional treatment (RR, 2.04; 95% CI, 1.88-2.21) vs no treatment, but was not higher with ablative treatment.
- Heterogeneity across studies.