- Findings from the pilot phase of a randomized controlled study suggest that thermal ablation has a treatment success rate similar to cryotherapy and large loop excision of the transformation zone (LLETZ) in patients with cervical precancer.
Why this matters
- These findings formed part of the evidence that led WHO to endorse the use of thermal ablation for ablative treatment in patients with cervical precancer in low-income and middle-income countries (LMICs).
- Final results are needed to confirm these findings.
- The pilot phase of a randomized controlled study of 750 patients with cervical precancer eligible for ablative therapy from LMICs, randomly assigned to thermal ablation, cryotherapy, or LLETZ.
- Funding: NIH.
- In the cryotherapy, thermal ablation, and LLETZ groups:
- 84%, 81%, and 84% of patients, respectively, attended the 6-month follow-up examination.
- The treatment success rate was 60%, 64%, and 67%, respectively (P=.52).
- 40%, 42%, and 47% of patients were cleared of high-risk HPV (P=.48).
- 6, 4, and 5 patients reported moderate- to worst-intensity pain immediately after the procedure.
- 1, 0, and 2 patients reported moderate- to worst-intensity pain at 2 weeks after treatment.
- No difference was seen in the patient satisfaction rate.
- Small sample size, short follow-up.