- In women with cervical and uterine cancers, sentinel lymph node (SLN) mapping with indocyanine green dye and near-infrared imaging identified significantly more sentinel and bilateral sentinel nodes vs standard isosulfan blue dye with white light.
Why this matters
- Indocyanine green with near-infrared imaging may become the new standard in SLN mapping.
- FILM study: 180 patients with cervical/uterine cancers were randomly assigned to SLN mapping with either isosulfan blue dye (with near-infrared imaging) followed by indocyanine green dye (with white light) or indocyanine green (with near-infrared imaging) followed by isosulfan blue (with white light).
- Funding: Novadaq.
- Noninferiority analysis in per-protocol population (n=163; 485 sentinel nodes).
- Mean number of nodes per patient, 3.2.
- Indocyanine green identified significantly more SLNs (97% vs 47%; Pnoninferiority<.0001 vs blue dye.>
- Indocyanine green identified ≥1 SLN (98% vs 76%; P<.0001 and bilateral sln class="">81% vs 32%; P<.0001 in more patients vs blue dye.>
- Mean number of nodes per patient, 3.1.
- Indocyanine green identified significantly more SLNs (96% vs 46%; Psuperiority<.0001>
- Indocyanine green identified ≥1 SLN (95% vs 74%; P<.0001 and bilateral sln vs p in more patients.>
- Sensitivity, negative predictive value not evaluated.