- A study using an objective measure of cognitive impairment, namely event-related potentials (ERPs), shows that chemotherapy-associated cognitive impairments are long-lasting and are worst among patients aged
Why this matters
- This is the largest study to date using objective measures of cognitive impairment and the first to show age-related effects.
- Cross-sectional cohort of 529 breast cancer patients (under study for P300 latency in ERPs) was divided into 3 groups: Group 1 was initially diagnosed breast cancer patients before chemotherapy; Group 2 was breast cancer patients during chemotherapy; Group 3 was breast cancer patients at a mean follow-up of 2.42 years postchemotherapy.
- Prolongation of P300 latency is indicative of cognitive impairment.
- Funding: National Natural Science Foundation of China.
- Groups 2 and 3 had significantly longer P300 latencies than Group 1 (each P<.001 but no difference between groups and>
- Group 1: 355.13±19.47 ms.
- Group 2: 364.74±15.73 ms.
- Group 3: 364.02±17.12 ms.
- Observational, cross-sectional design.