Children with atopic dermatitis at greater risk for multiple allergies

Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.
Takeaway
  • Children with atopic dermatitis (AD) are at greater risk of being sensitized to multiple allergens. 
Why this matters
  • Conclusion supports hypothesis that sensitization may occur through compromised skin barrier as a result of AD.
  • Polysensitization is common but not well understood.
  • Early AD is a risk factor for severe asthma in children.
  • First study to examine link between AD and polysensitization in children.
Study design
  • Retrospective cross-sectional analysis of the hospital charts of 1743 children aged <17 y whose files documented AD and other skin disorders.
  • All children included in the study had been referred for allergic symptoms and had blood test measuring presence of IgE to the 10 most common inhaled and food allergens.
  • Funding: None.
Key results
  • Children with AD had a more than 5-fold greater risk for polysensitization compared with children without AD.
  • Polysensitization was not linked to any other skin disorders.
  • Polysensitization most commonly seen in children aged 4-11 y.
  • The majority of polysensitization was as a result of inhaled allergens.
Limitations
  • Retrospective design.
  • No clinical data on severity of AD.
  • Possible selection bias.