Children with psoriasis at high risk for co-morbidities

Access to the full content of this site is available only to registered healthcare professionals. Register to read more

New findings have highlighted the importance of screening children with psoriasis, and particularly children who are obese, for co-morbidities.

While it is established that adult patients with psoriasis are at risk for co-morbidities such as metabolic syndrome, depression and anxiety, most of the evidence for similar associations in paediatric populations is based on small case series or small population-based studies.

In this new study, researchers set out to determine the risk of a number of conditions in 29,957 children with psoriasis and 29,957 children without psoriasis, after adjusting for obesity. They found children with psoriasis are at greater risk of developing obesity, hyperlipidaemia, hypertension, diabetes, metabolic syndrome, polycystic ovarian syndrome, and non-alcoholic liver disease, than children without psoriasis. Obesity was a strong risk factor for each comorbidity, even in those without psoriasis, with hazard ratios ranging from 2.26 to 18.11.

Writing in JAMA Dermatology, the authors said: "While screening for comorbidities should be considered for all children who have psoriasis, our results highlight the particular importance of screening obese patients because obesity is a much larger contributor to comorbidity development.”