Cholesterol efflux capacity predicts graft failure in renal transplant

Access to the full content of this site is available only to registered healthcare professionals. Register to read more
Takeaway
  • In patients undergoing renal transplant, cholesterol efflux capacity is a strong predictor of graft failure, independent of plasma HDL-C levels
Methods
  • Study population: cohort of renal transplant recipients (n=495, median follow-up: 7.0 years)
  • Cholesterol efflux capacity was quantified at baseline using incubation of human macrophage foam cells with apolipoprotein B-depleted plasma
Results
  • No difference in baseline efflux capacity between deceased patients and surviv...