Cholesterol efflux capacity predicts graft failure in renal transplant

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  • In patients undergoing renal transplant, cholesterol efflux capacity is a strong predictor of graft failure, independent of plasma HDL-C levels
  • Study population: cohort of renal transplant recipients (n=495, median follow-up: 7.0 years)
  • Cholesterol efflux capacity was quantified at baseline using incubation of human macrophage foam cells with apolipoprotein B-depleted plasma
  • No difference in baseline efflux capacity between deceased patients and surviv...