Chronic hyperglycaemia tied to higher risk for kidney stone disease

  • Geraghty R & al.
  • BMJ Open
  • 19 Jan 2020

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • In patients with diabetes mellitus (DM), chronic hyperglycaemia was associated with an increased risk of developing kidney stone disease (KSD).

Why this matters

  • Tight glycaemic control and weight loss should be considered for their primary preventative effects on KSD and included as a part of the long-term management of KSD in patients with DM.

Study design

  • Meta-analysis included 13 observational studies after a search across MEDLINE, Cochrane Library and others.
  • Funding: None disclosed.

Key results

  • In subgroup analyses, DM was significantly associated with an increased risk for KSD (adjusted risk ratio [aRR], 1.23; 95% CI, 0.94-1.51; P<.001>
  • The risk for KSD was significantly higher in patients with DM in cross-sectional or case-control studies (adjusted OR [aOR], 1.32; 95% CI, 1.21-1.43; P<.001>
  • Impaired glucose tolerance (IGT) significantly increased the risk for KSD (aOR, 1.26; 95% CI, 0.94-1.58).
  • Combination of DM and IGT was associated with an increased risk for KSD (aOR, 1.32; 95% CI, 1.17-1.49; P<.0001>
  • In cross-sectional studies, metabolic syndrome significantly increased the risk for KSD (OR, 1.35; 95% CI, 1.16-1.54; P<.0001>

Limitations

  • Heterogeneity among studies.
  • Risk of publication bias.