- In patients with diabetes mellitus (DM), chronic hyperglycaemia was associated with an increased risk of developing kidney stone disease (KSD).
Why this matters
- Tight glycaemic control and weight loss should be considered for their primary preventative effects on KSD and included as a part of the long-term management of KSD in patients with DM.
- Meta-analysis included 13 observational studies after a search across MEDLINE, Cochrane Library and others.
- Funding: None disclosed.
- In subgroup analyses, DM was significantly associated with an increased risk for KSD (adjusted risk ratio [aRR], 1.23; 95% CI, 0.94-1.51; P<.001>
- The risk for KSD was significantly higher in patients with DM in cross-sectional or case-control studies (adjusted OR [aOR], 1.32; 95% CI, 1.21-1.43; P<.001>
- Impaired glucose tolerance (IGT) significantly increased the risk for KSD (aOR, 1.26; 95% CI, 0.94-1.58).
- Combination of DM and IGT was associated with an increased risk for KSD (aOR, 1.32; 95% CI, 1.17-1.49; P<.0001>
- In cross-sectional studies, metabolic syndrome significantly increased the risk for KSD (OR, 1.35; 95% CI, 1.16-1.54; P<.0001>
- Heterogeneity among studies.
- Risk of publication bias.