- Prescription opioid misuse is higher in patients with chronic pain and comorbid depression.
- Odds of prescription opioid misuse increased with depression severity.
Why this matters
- Chronic depression is an important contributor to opioid misuse; patients with chronic pain and comorbid depression are more likely to be prescribed opioids.
- This patient population should therefore be evaluated and monitored.
- 554 patients aged ≥18 years with chronic non-cancer pain received prescription opioids.
- Funding: Indivior Pharmaceuticals.
- 56.3% of patients were screened positive for depression.
- Rate of prescription opioid misuse was 29.1%.
- Patients with depression were at significantly higher risk for opioid misuse (aOR, 3.63; 95% CI, 1.71-7.7) vs those without depression.
- Risk for opioid misuse increased with increasing severity of depression:
- Moderate depression: aOR, 3.71 (95% CI, 1.01-13.76).
- Moderate-severe depression: aOR, 6.28 (95% CI, 1.6-24.57).
- Severe depression: aOR, 14.66 (95% CI, 3.28-65.52).
- Cross-sectional design.