- Chronic pain in adolescence is tied to later opioid misuse.
- Depressive, anxiety symptoms are not predictive.
Why this matters
- Early targeted screening might decrease opioid misuse.
- 28.3% of adults (weighted percentage) in this study reported prescription opioid misuse.
- 24% of those reporting chronic pain in adolescence reported opioid misuse in early adulthood vs 18.8% among those without such a history (P<.001>
- aOR, 1.24 (95% CI, 1.05-1.46; P=.013).
- Use in adulthood generally was also higher among those with chronic pain history: 33% vs 27% (P<.001>
- aOR, 1.19 (95% CI, 1.04-1.36; P=.01).
- Women were less likely to misuse (aOR, 0.67; 95% CI, 0.52-0.86).
- A history of childhood trauma increased odds (aOR, 1.38; 95% CI, 1.21-1.58).
- Black, Hispanic participants were less likely to report misuse vs white participants:
- Black adolescents: aOR, 0.40 (95% CI, 0.23-0.69);
- Hispanic adolescents: aOR, 0.42 (95% CI, 0.25-0.71).
- Depression, anxiety, self-reported fair-poor physical health were not tied to misuse.
- National Longitudinal Study of Adolescent to Adult Health data for 14,784 participants.
- Primary outcome: prescription opioid use in early adulthood and adulthood.
- Funding: International Association for the Study of Pain; NIH.
- Self-report for opioid misuse.
- Questions assessing opioid misuse differed for different cohorts (waves).