- Overall incidence of depression and anxiety was higher in patients with chronic rhinosinusitis (CRS), especially those with nasal polyps, than in those without the condition, according to a large population study in South Korea.
Why this matters
- Study findings can help clinicians monitor patients with CRS for signs of depression and anxiety, possibly preventing mental health issues or treating them early.
- This retrospective study propensity matched 16,224 patients with CRS (CRS without nasal polyp [CRSsNP], n=10,763; CRS with nasal polyp [CRSwNP], n=5461) and 32,448 patients without CRS.
- Funding: Korea Health Industry Development Institute.
- During 11-years of follow-up, the overall incidence of depression (aHR, 1.54; 95% CI, 1.48-1.61) and anxiety (aHR, 1.57; 95% CI, 1.52-1.62) was significantly higher in the group with vs without CRS.
- Likelihood for developing depression and anxiety was higher in the CRSsNP vs the CRSwNP group:
- CRSsNP: aHRdepression, 1.61 (95% CI, 1.54-1.69); aHRanxiety, 1.63 (95% CI, 1.57-1.69).
- CRSwNP: aHRdepression, 1.41 (95% CI, 1.32-1.50); aHRanxiety, 1.45 (95% CI, 1.38-1.52).
- Potential confounding factors not adjusted for.
- CRS diagnosis dependent on Korean Classification of Diseases diagnostic codes.
Coauthored with Antara Ghosh, PhD