- Both under- and oversleeping are tied to poorer health-related QoL (HRQoL) in patients with predialysis chronic kidney disease (CKD).
Why this matters
- Nearly 20% of patients with predialysis CKD do not get the optimal amount of sleep.
- Cross-sectional analysis of KNOW-CKD data for 1910 adults (62% men; mean age, 52 years) with CKD; 33% had diabetes and 11% had cardiovascular disease.
- 10.7% slept ≤5 hours/day (short-sleepers), 7.1% slept ≥9 hours/day (long-sleepers); 29.7% slept 7 hours/day.
- Primary outcomes were scores/100 on the Short Form-36 Health Survey physical and mental components.
- Funding: None disclosed.
- An inverted U-shaped relationship was observed between sleep duration and HRQoL; 7-hour sleepers had the highest HRQoL.
- 7-hour sleepers had higher mean scores in physical QoL (76±16 vs 67±21 and 62±21; Ptrend<.01 mental qol measures to achieve significance.>
- In multivariate analysis, short-sleepers and long-sleepers were significantly more likely to report lower physical (OR=3.23 [95% CI, 1.86-5.60] and OR=2.80 [95% CI, 1.55-5.03], respectively) and mental QoL (OR=2.37 [95% CI, 1.43-3.94] and OR=2.08 [95% CI, 1.20-3.60], respectively).
- Mean estimated glomerular filtration rate (mL/minute/1.73 m2) was higher in 7-hour sleepers vs short- and long-sleepers (55±31 vs 54±30 and 39±26, respectively; Ptrend <.001>
- Cannot prove causal relationship.