CKD: sleep duration tied to health-related QoL

  • Clin J Am Soc Nephrol

  • curated by Yael Waknine
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Both under- and oversleeping are tied to poorer health-related QoL (HRQoL) in patients with predialysis chronic kidney disease (CKD).

Why this matters

  • Nearly 20% of patients with predialysis CKD do not get the optimal amount of sleep.

Study design

  • Cross-sectional analysis of KNOW-CKD data for 1910 adults (62% men; mean age, 52 years) with CKD; 33% had diabetes and 11% had cardiovascular disease.
  • 10.7% slept ≤5 hours/day (short-sleepers), 7.1% slept ≥9 hours/day (long-sleepers); 29.7% slept 7 hours/day.
  • Primary outcomes were scores/100 on the Short Form-36 Health Survey physical and mental components.
  • Funding: None disclosed.

Key results

  • An inverted U-shaped relationship was observed between sleep duration and HRQoL; 7-hour sleepers had the highest HRQoL.
  • 7-hour sleepers had higher mean scores in physical QoL (76±16 vs 67±21 and 62±21; Ptrend<.01 mental qol measures to achieve significance.>
  • In multivariate analysis, short-sleepers and long-sleepers were significantly more likely to report lower physical (OR=3.23 [95% CI, 1.86-5.60] and OR=2.80 [95% CI, 1.55-5.03], respectively) and mental QoL (OR=2.37 [95% CI, 1.43-3.94] and OR=2.08 [95% CI, 1.20-3.60], respectively).
  • Mean estimated glomerular filtration rate (mL/minute/1.73 m2) was higher in 7-hour sleepers vs short- and long-sleepers (55±31 vs 54±30 and 39±26, respectively; Ptrend <.001>

Limitations

  • Cannot prove causal relationship.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit