- Patients with chronic myeloid leukemia (CML) have significantly increased risk of developing a second malignant neoplasm (SMN).
- Risk was highest in males and most pronounced for cancers of the respiratory tract, genitourinary (GU) tract, and skin.
Why this matters
- As survival continues to extend in patients with CML, there is an increasing need to elucidate risk of late complications.
- Study to investigate risk of SMNs in 3407 patients with CML.
- Data were sourced from the Surveillance Epidemiology and End Results (SEER-18) cancer registries for patients diagnosed with CML between 2001 and 2014.
- Funding: None.
- 4.99% of patients went on to develop an SMN at a median of 36.5 (range, 6-160) months following CML diagnosis.
- Standardized incidence ratio (SIR) for SMNs was 1.40 (95% CI, 1.19-1.62).
- Significantly increased risk of the following cancers:
- Respiratory tract: SIR, 1.69; 95% CI, 1.15-2.4.
- GU tract: SIR, 1.39; 95% CI, 1.04-1.81.
- Skin cancer excluding basal cell and squamous cell carcinoma: SIR, 1.94; 95% CI, 1.04-3.32.
- Risk of SMN was increased in males: SIR, 1.57; 95% CI, 1.29-1.88.
- Patients with GU malignancy post-CML had inferior OS (P=.018) vs matched patients with de novo malignancy.
- Retrospective data.