Cognitive decline of stroke patients associated with amyloid-β deposition

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  • PET-detected deposition of amyloid-β (Aβ) is associated with cognitive decline of stroke/transient ischemic attack patients.

Key results

  • Patients with Alzheimer’s disease (AD)-like Aβ deposition showed a significant decline in cognitive performance on the Mini-Mental State Examination (MMSE) (p=.020), while non-Aβ patients did not (p=.208).
  • Rates of cognitive decline were greater on the MMSE and Montreal Cognitive Assessment in Aβ patients compared with non-Aβ patients (p=.023 and p=.03, respectively).

Study design

  • 72 stroke/transient ischemic attack patients without AD were analyzed by PET for Aβ deposition and tested for cognitive impairments by the MMSE and Montreal Cognitive Assessment over 3 years.