- Poorer performance in both executive function and memory tests was associated with increased risk for all-cause, cardiovascular (CV) and non-CV mortality in dementia-free older adults.
- This association was independent of CV risk factors and diseases, brain structural abnormalities, and cerebral blood flow.
Why this matters
- Although the link between global cognitive impairment and mortality is well-established, few studies have demonstrated conflicting results regarding the association between domain-specific cognitive function and mortality.
- Cognitive assessment along with other clinical tools could be used to identify older adults at a greater risk for mortality.
- 547 dementia-free participants (56.5% male, mean age 78 years) were included from the nested magnetic resonance imaging substudy of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).
- Funding: Bristol-Myers Squibb.
- After adjustment for confounders, lower performance in executive function was associated with increased risk for all-cause (HR, 1.49; 95% CI, 1.31-1.70), CV (HR, 1.69; 95% CI, 1.36-2.11) and non-CV (HR, 1.36; 95% CI, 1.15-1.62) mortality (P<.001 for all>
- Similarly, poorer performance in memory tests was linked to a higher risk for all-cause (HR, 1.47; 95% CI, 1.29-1.68), CV (HR, 1.45; 95% CI, 1.15-1.83) and non-CV (HR, 1.49; 95% CI, 1.27-1.76) mortality (P<.001 for all>
- This association was similar in older adults with a variety of brain structural abnormalities and cerebral blood flow (all Pinteraction>.05).
- Study has limited generalisability to older adults with dementia and higher risk for CV disease.