Cognitive impairment in elderly linked to increased blood pressure variability

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  • Cognitive impairment in elderly is linked to increased blood pressure (BP) variability.

Study design

  • 353 community residents aged ≥65 y underwent ambulatory BP monitoring and Mini Mental State Examination (MMSE) and Cambridge Cognitive Examination (CAMCOG) at baseline and 5 y follow-up.
  • Funding: Study funded by Health Foundation, London, England, and others.

Key results

  • Independent of demographic and cardiovascular risk factors, greater daytime systolic BP variability was associated with worse baseline CAMCOG total and subscores, and daytime diastolic BP variability with worse total CAMCOG, CAMCOG executive score, and MMSE.
  • Daytime systolic BP variability independently predicted greater 5 y decline in total CAMCOG and MMSE (P<.05), even after adjustment for stroke history, use of cardioactive medication, and baseline MMSE/CAMCOG.
  • Mean BP was not associated with baseline cognitive function.


  • Possible selection bias.
  • Difficulty in measuring BP variability.
  • Lack of brain imagi...