- Compared with usual care, at 6 months, collaborative care management (CCM) produces a greater depression remission rate among patients with depression and comorbid personality disorder (PD).
- Patients in both groups with comorbid PD fared worse than patients with depression alone.
Why this matters
- PD and major depressive disorder (MDD) are often comorbid, and PD interferes with treatment of other mental disorders.
- The increased contact with care providers in CCM may help patients with PD recognize maladaptive interpersonal patterns.
- Retrospective cohort study included 9614 patients (CCM, n=5715; usual care, n=3899) with MDD.
- Patient Health Questionnaire-9 was used to measure clinical outcomes at 6 months.
- Funding: None.
- 7.1% of patients with MDD were diagnosed with comorbid PD.
- Among patients with MDD and PD, remission rates were better with CCM vs usual care (25.2% vs 11.5%; P=.002).
- An increased rate of depressive symptoms was seen in patients with PD receiving usual care (67.7% vs 51.7%; P=.004).
- Diagnosis of PD was associated with:
- Decreased ORs for remission (OR, 0.369; 95% CI, 0.201-0.676); and
- Increased ORs for PDs (OR, 2.123; 95% CI, 1.359-3.318).
- Potential underdiagnosis of PD within the cohort.
Coauthored with Chitra Ravi, MPharm