- For colonoscopy, adding dexmedetomidine (Precedex, Hospira) to propofol (Diprivan, Fresenius Kabi USA, LLC) results in more patients with delayed discharge readiness compared with propofol alone.
Why this matters
- Propofol is often used as the sole anesthesia drug in colonoscopies and may lead to vital-sign disturbances in large doses.
- Giving dexmedetomidine with propofol can decrease the physiologic stress response during surgery.
- Few data addressed whether this combination would affect discharge readiness after outpatient colonoscopy.
- 101 participants were included in the per-protocol analysis.
- Discharge readiness within 30 minutes of procedure end, propofol-dexmedetomidine vs propofol-placebo: 51% (26/51) vs 88% (44/50; P<.001>
- Delays driven mostly by patient inability to ambulate.
- Patients receiving propofol-dexmedetomidine had lower propofol consumption.
- No between-group difference in bradycardia, apnea.
- Single-center randomized controlled double-blind noninferiority trial of adults undergoing elective ambulatory colonoscopy (n=114).
- Participants were randomly assigned to anesthesia with propofol-dexmedetomidine vs propofol-placebo.
- Intervention consisted of a single 0.3 μg/kg bolus of dexmedetomidine.
- Outcome: percentage of patients ready for discharge within 30 minutes of the end of the procedure, using validated discharge-readiness .
- No external funding.
- Patient movements not assessed.
- Only 1 dose of dexmedetomidine assessed.
- No intention-to-treat analysis.