Comorbid fibromyalgia/endometriosis tied to higher odds of autoimmune disease

  • Greenbaum H & al.
  • Am J Reprod Immunol
  • 25 Jan 2019

  • curated by Miriam Davis, PhD
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • 3 autoimmune diseases (ADs; Sjogren syndrome, IBD, and systemic lupus erythematosus [SLE]) appear to be up to 4 times more likely in women with comorbid fibromyalgia/endometriosis.

Why this matters

  • Consider screening for ADs among women with fibromyalgia/endometriosis.

Study design

  • Cross-sectional cohort of 781,571 adult women in an Israeli health plan in 2015.
  • Funding: None.

Key results

  • Across the whole population of adult women, 6647 were diagnosed with endometriosis (8.5 per 1000), 25,425 with fibromyalgia, and 401 with both diagnoses (0.5 per 1000).
  • Mean age of diagnosis of endometriosis was 42±9.8 years, and for fibromyalgia it was 55±14 years.
  • According to adjusted analyses (eg, age, socioeconomic status, BMI), diagnosis of endometriosis/fibromyalgia was associated with these excess risks for AD compared with the general population:
    • SLE (aOR, 4.11; P<.001>
    • Sjogren syndrome (aOR, 3.08; P=.002).
    • IBD (aOR, 2.97; P<.001>
  • Also elevated in this population was anxiety or depression (aOR, 1.73; P<.001 and use of antidepressants p>

Limitations

  • Cross-sectional design.
  • Diagnosis of endometriosis may be underestimated because many are asymptomatic.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit