- 3 autoimmune diseases (ADs; Sjogren syndrome, IBD, and systemic lupus erythematosus [SLE]) appear to be up to 4 times more likely in women with comorbid fibromyalgia/endometriosis.
Why this matters
- Consider screening for ADs among women with fibromyalgia/endometriosis.
- Cross-sectional cohort of 781,571 adult women in an Israeli health plan in 2015.
- Funding: None.
- Across the whole population of adult women, 6647 were diagnosed with endometriosis (8.5 per 1000), 25,425 with fibromyalgia, and 401 with both diagnoses (0.5 per 1000).
- Mean age of diagnosis of endometriosis was 42±9.8 years, and for fibromyalgia it was 55±14 years.
- According to adjusted analyses (eg, age, socioeconomic status, BMI), diagnosis of endometriosis/fibromyalgia was associated with these excess risks for AD compared with the general population:
- SLE (aOR, 4.11; P<.001>
- Sjogren syndrome (aOR, 3.08; P=.002).
- IBD (aOR, 2.97; P<.001>
- Cross-sectional design.
- Diagnosis of endometriosis may be underestimated because many are asymptomatic.