- Roughly one-quarter of Brazilian children born to mothers who experienced a rash during pregnancy were diagnosed with congenital Zika syndrome (CZS) during the first year of life.
Why this matters
- Monitor infants whose mothers experience Zika virus (ZIKV) rash during pregnancy beyond birth even if they are asymptomatic.
- Timely identification of developmental, cognitive, neurologic, motor abnormalities may facilitate interventions to slow disability.
- 108 children: 40% (43) to ZIKV RT-qPCR-positive mother, 24% (26) RT-qPCR-negative, 36% (39) to mothers with suspected untested ZIKV.
- Maternal rash reported during first (29%, 31), second (45%, 49), third (20%, 22) trimesters and before pregnancy (5.5%, 6).
- 24% (26) children diagnosed with CZS, 46% (12) at birth, 54% (14) during follow-up to 10 months.
- 69% (18) CZS children had microcephaly, 15% (6) diagnosed at birth, 6 postbirth; 100% had developmental delays, motor abnormalities.
- Longitudinal, observational study assessing developmental progress of children from birth to 18 months whose mothers developed ZIKV rash during ≤3 months pregestation.
- Funding: Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior.
- Adherence challenges.
- In utero exposure to ZIKV, other flaviviruses unmeasured.
- Observational bias.
- Selection bias, nongeneralizable.