- A meta-analysis of 58 studies finds that the pooled global prevalence of comorbid osteoporosis among patients with COPD is 38%.
- Risk factors for comorbid osteoporosis are being underweight and having sarcopenia.
Why this matters
- Osteoporosis in COPD is likely attributable to higher systemic inflammation.
- Osteoporosis in COPD is largely undiagnosed until bone fractures occur.
- Patients with COPD should be screened for osteoporosis and its risk factors.
- Meta-analysis of 58 cohort studies (55 of which were cross-sectional), after search of EMBASE, CINAHL MEDLINE, and PubMed.
- Funding: None disclosed.
- Pooled global prevalence of osteoporosis was 38% (95% CI, 34%-43%) in COPD patients (I2=93%) and 15% in controls (P<.01>
- Having COPD (vs control) increased the odds of osteoporosis (OR, 2.99; 95% CI, 2.09-4.27).
- Risk factors for osteoporosis in COPD patients were:
- Being underweight (BMI 2): OR, 4.26; 95% CI, 1.07-16.99.
- Having sarcopenia: OR, 3.65; 95% CI, 1.45-9.16.
- Decreased risk factors for osteoporosis in COPD patients were:
- Increased BMI of 1 kg/m2: OR, 0.80; 95% CI, 0.76-0.85.
- Increased fat-free mass index of 1 kg/m2: OR, 0.64; 95% CI, 0.49-0.83.
- No longitudinal studies.
- Largely cross-sectional cohort studies.
- High heterogeneity in prevalence of osteoporosis.