COPD: antiplatelet therapy and all-cause mortality | COPD

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  • Antiplatelet therapy in chronic obstructive pulmonary disease (COPD) may significantly lower all-cause mortality.


Study design/methods

  • Literature search identified 5 studies including 11117 COPD patients (3069 with acute exacerbation; 33% with ischemic heart disease [IHD]) for systematic review and meta-analysis.


Key Results

  • Antiplatelet therapy was common (47%; 95%CI 46%-48%; range 26%-61%).
  • All-cause mortality was significantly lower in COPD patients receiving antiplatelet treatment (odds ratio [OR] 0.81; 0.75-0.88), both in outpatients and in those with acute exacerbation.
  • Antiplatelet therapy was effective independent of potential confounders including IHD, cardiovascular drugs and cardiovascular risk factors, based on meta-regression.



  • Limitations include those inherent in the included studies.


Why this matters

  • Patients with chronic obstructive pulmonary disease (COPD) are at high cardiovascular risk due to chronic inflammation and heightened platelet activation; meta-analysis suggests significantly lower all-cause mortality with antiplatelet therapy.